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目的:探讨N-myc下游调节基因1(N-myc downstream-regulated gene 1,NDRG1)在乳腺癌中表达。方法:收集乳腺癌病例及相应的临床资料包括随访资料,应用免疫组织化学技术检测良性病变(BBD)47例,无淋巴结转移乳腺癌(NMBC)83例,有淋巴结转移乳腺癌(MBC)107例及配对淋巴结转移灶(PLNM)107例中NDRG1的表达,分析NDRG1表达与乳腺癌临床病理指标间(患者年龄、肿块大小、临床分期、组织学类型和分级、淋巴结转移、雌孕激素受体和c-erb B2水平、绝经史)及生存状态的关系。结果:通过免疫组化技术检测乳腺癌中NDRG1的表达,结果显示阳性表达率分别为BBD(95.7%,45/47),NMBC(96.4%,80/83),MBC(98.1%,105/107),PMLN(90.7%,97/107),MBC组织中NDRG1阳性表达率显著高于PMLN中阳性表达率(P=0.021)。NDRG1与组织学分级相关(P=0.041),即分化越差的癌表达NDRG1越强。NDRG1的表达状态与乳腺癌患者的生存预后无显著性相关(P=0.196)。结论:NDRG1表达与乳腺癌淋巴结转移和分化有一定关系。
Objective: To investigate the expression of N-myc downstream-regulated gene 1 (NDRG1) in breast cancer. Methods: Forty-seven cases of benign disease (BBD), 83 cases of non-lymph node metastatic breast cancer (NMBC) and 107 cases of lymph node metastatic breast cancer (MBC) were collected from patients with breast cancer and corresponding clinical data including follow-up data. And paired lymph node metastasis (PLNM) 107 cases of NDRG1 expression, analysis of NDRG1 expression and clinicopathological parameters between breast cancer (patient age, tumor size, clinical stage, histological type and grade, lymph node metastasis, estrogen and progesterone receptor and c-erb B2 levels, menopause) and the relationship between survival status. Results: The positive rate of NDRG1 expression in breast cancer was detected by immunohistochemistry. The positive rates of BBD were 95.7%, 45/47, ), PMLN (90.7%, 97/107). The positive rate of NDRG1 in MBC was significantly higher than that in PMLN (P = 0.021). NDRG1 was associated with histological grade (P = 0.041), indicating that the more differentiated cancers express the stronger NDRG1. There was no significant correlation between the expression of NDRG1 and the prognosis of patients with breast cancer (P = 0.196). Conclusion: The expression of NDRG1 is related to lymph node metastasis and differentiation of breast cancer.