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目的:探讨左氧氟沙星注射液不良反应(ADR)发生情况及其影响因素,提高临床用药安全性。方法:回顾性分析1 748例左氧氟沙星注射液治疗的患者临床资料,统计ADR发生的发生特点和发生率,采用单因素分析和多因素Logistic回归分析评价其影响因素。结果:发生ADR共计48例,ADR发生率为2.75%。多因素Logistic回归分析显示ADR的独立危险因素有年龄(OR=1.687,95%CI:1.447~1.967)、过敏史(OR=2.257,95%CI:1.898~2.684)、用药剂量(OR=1.815,95%CI:1.582~2.082)、疗程(OR=1.783,95%CI:1.516~2.097)和联合用药(OR=1.729,95%CI:1.488~2.009)。结论:左氧氟沙星注射液ADR发生临床症状较轻,但累及器官和系统广,并且与年龄、过敏史、用药剂量、疗程和联合用药有关。临床医生必须根据这些因素,提高用药注意事项,以降低ADR风险。
Objective: To investigate the incidence and influencing factors of adverse reactions (ADR) of levofloxacin injection and improve the safety of clinical medication. Methods: The clinical data of 1 748 patients treated with levofloxacin injection were retrospectively analyzed. The characteristics and incidence of ADR were analyzed retrospectively. Univariate analysis and multivariate Logistic regression analysis were used to evaluate the influencing factors. Results: A total of 48 cases of ADR occurred, the incidence of ADR was 2.75%. Multivariate logistic regression analysis showed that the independent risk factors of ADR were age (OR = 1.687, 95% CI: 1.447-1.967), history of allergy (OR = 2.257, 95% CI: 1.898-2.684) (OR = 1.783, 95% CI: 1.516 ~ 2.097) and combination therapy (OR = 1.729, 95% CI: 1.488-2.009). Conclusion: The clinical symptoms of levofloxacin ADR are mild, but involve organs and system widely, and are related to age, history of allergy, dosage, course of treatment and combination therapy. Clinicians must improve medication considerations to reduce the risk of ADR based on these factors.