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Aim:To investigate the effects of magnesium lithospermate B(MLB)isolatedfrom Salviae miltiorrhizae on renal microcirculation,and renal and systemic he-modynamics in Sprague-Dawley rats.Methods:MLB(10,30,and 60 mg/kg)wasinjected intravenously and renal blood flow(RBF),renal cortical microperfusion(RCM),and systemic hemodynamic function parameters including heart rate(HR),mean arterial pressure(MAP),left ventricular systolic pressure(LVSP),left ven-tricular end-diastolic pressure(LVEDP),and maximal velocity of pressure increase(dp/dt_(max))were measured for 45 min after administration.Results:IntravenousMLB at doses of 10,30,and 60 mg/kg increased RCM significantly,but had noobvious effects on RBF or systemic hemodynamics.The effect of MLB on RCMreached its peak 15 rain after injection and returned to baseline after 45 min.Up to60 mg/kg MLB increased RCM by 62.4%±20.2%(changes from baseline,P<0.01),whereas RBF(3.7%±9.7% vs baseline)and renal vascular resistance(-1.4%±9.1%vs baseline)did not obviously change.Conclusion:These results indicate thatMLB ameliorates renal microcirculation in a dose-dependent manner,which maybe related to the renoprotective effects of MLB.
Aim: To investigate the effects of magnesium lithospermate B (MLB) isolatedfrom Salviae miltiorrhizae on renal microcirculation, and renal and systemic hemodynamics in Sprague-Dawley rats. Methods: MLB (10,30 and 60 mg / kg) wasinjected intravenously and (RBF), renal cortical microperfusion (RCM), and systemic hemodynamic function parameters including heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ven- tricular end- diastolic pressure LVEDP), and maximal velocity of pressure increase (dp / dt max) were measured for 45 min after administration. Results: Intravenous MLB at doses of 10, 30, and 60 mg / kg increased RCM significantly, but had noobvious effects on RBF or systemic hemodynamics. The effect of MLB on RCMreached its peak 15 min after injection and returned to baseline after 45 min. Up to 60 mg / kg MLB increased RCM by 62.4% ± 20.2% (changes from baseline, P <0.01) (3.7% ± 9.7% vs baseline) and renal vascular resistance (-1.4% ± 9.1% vs baseline) d id not obviously change. Conlusion: These results indicate that MLB ameliorates renal microcirculation in a dose-dependent manner, which maybe related to the renoprotective effects of MLB.