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器官移植的最终目的是获得移植器官的长期存活耐受而无免疫排斥。mTOR信号通路在器官移植免疫中起重要作用。雷帕霉素作为mTOR抑制剂可抑制T细胞激活、促进调节性T细胞增殖、抑制树突状细胞成熟,发挥抗排斥作用。雷帕霉素以其无肾毒性以及抗内皮细胞增殖等特性使临床获得了减轻甚至预防CNIs肾毒性和抗肿瘤的新途径,为肝移植受者免疫抑制方案提供了新的解决途径。
The ultimate goal of organ transplantation is to obtain long-term survival tolerance of transplanted organs without immune rejection. The mTOR signaling pathway plays an important role in organ transplantation immunity. Rapamycin as an inhibitor of mTOR can inhibit T cell activation, promote regulatory T cell proliferation, inhibit dendritic cell maturation and exert anti-rejection. Its non-nephrotoxicity and anti-endothelial cell proliferation have led to the clinical availability of new avenues for alleviating or even preventing nephrotoxicity and antitumor activity of CNIs, providing a new solution to immunosuppressive regimens for liver transplant recipients.