目的观察药物致急性间质性肾炎(D-AIN)的临床特点,提高D-AIN的诊治水平。方法对24例明确由药物所致的急性间质性肾炎(AIN)进行回顾性分析。结果经治疗3个月后全部患者的尿蛋白均转阴,肾功能恢复至基线水平,93.55%患者的尿N一乙酰一8氨基葡萄糖苷酶(NAG)明显下降。结论 D-AIN的临床表现无特异性,肾活检是确诊的惟一手段,早期确诊后及时停药,早期应用激素,必要时加用环磷酰胺,大多数预后良好。 Objective To observe the clinical features of drug-induced acute interstitial nephritis (D-AIN) and to improve the diagnosis and treatment of D-AIN. Methods A retrospective analysis of 24 patients with acute interstitial nephritis (AIN) caused by drugs was retrospectively analyzed. Results All the patients’ urinary protein turned negative after 3 months of treatment, and the renal function recovered to the baseline level. The urine N-acetylglucosaminidase (NAG) was significantly decreased in 93.55% of the patients. Conclusion The clinical manifestations of D-AIN are nonspecific. Kidney biopsy is the only means of diagnosis. Early diagnosis after discontinuation of early diagnosis, early use of hormones, cyclophosphamide if necessary, most of the prognosis is good.