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目的:探讨固本防哮饮配合捏脊疗法治疗小儿哮喘缓解期(肺脾气虚证)的临床疗效。方法:选择肺脾气虚型小儿哮喘为研究对象,在知情自愿的前提下,随机分为治疗组和对照组。治疗组给予固本防喘饮联合捏脊疗法,对照组给予布地奈德雾化吸入治疗。经治疗后,观察两组患儿治疗后症状体征变化,分析比较两组肺功能指标、炎性细胞因子以及免疫指标变化。结果:治疗组治疗后总有效率为88.3%,对照组为73.3%,治疗组优于对照组(P<0.05);治疗后,治疗组FEV1、FEV1%和FEV1/FVC均明显高于治疗前和对照组治疗后指标(P<0.05),而对照组治疗前后肺功能指标无明显差异(P>0.05);治疗后,治疗组IL-5,IL-4含量均显著低于治疗前和对照组治疗后,而γ-IFN含量均显著高于治疗前和对照组治疗后指标(P<0.05);经治疗后,治疗组CD3+、CD4+、CD4+/CD8+细胞均显著升高(P<0.05),且均显著高于对照组(P<0.05),CD8+显著低于对照组(P<0.05),对照组治疗前后免疫指标差异无统计学意义(P>0.05)。结论:固本防哮饮配合捏脊疗法治疗肺脾气虚型哮喘,能够有效改善患儿气道炎性反应,调节机体免疫机能,提高缓解期患儿的临床治疗效果。
Objective: To investigate the curative effect of Guben anti-asthma drink combined with chiropractic therapy on children with asthma remission (pulmonary spleen deficiency syndrome). Methods: Select asthmatic children with asthenia spleen asthenia as the research object, on the premise of informed consent, were randomly divided into treatment group and control group. The treatment group was given Guben anti-asthma drink combined with chiropractic, the control group was given budesonide inhalation therapy. After treatment, the symptoms and signs of the two groups were observed after treatment, and the changes of pulmonary function, inflammatory cytokines and immune indexes were analyzed and compared. Results: After treatment, the total effective rate was 88.3% in the treatment group and 73.3% in the control group, which was superior to the control group (P <0.05). After treatment, FEV1, FEV1% and FEV1 / FVC in the treatment group were significantly higher than those before treatment And control group (P <0.05), while there was no significant difference between before and after treatment in the control group (P> 0.05). After treatment, the levels of IL-5 and IL-4 in the treatment group were significantly lower than those before treatment and before treatment After treatment, the levels of γ-IFN were significantly higher than those before treatment and after treatment (P <0.05). After treatment, the levels of CD3 +, CD4 +, CD4 + / CD8 + , Both of which were significantly higher than those of the control group (P <0.05). The levels of CD8 + in the control group were significantly lower than those in the control group (P <0.05). There was no significant difference in the immunological indexes before and after treatment in the control group (P> 0.05). Conclusion: Guben anti-asthma drink combined with chiropractic treatment of asthenia of lung, spleen and qi deficiency can effectively improve children’s airway inflammatory response, regulate immune function, and improve the clinical effect of treatment in children with remission.