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本研究旨在探讨肝素对实验性增生性玻璃体视网膜病变PVR的疗效及毒性。用新鲜兔自血0.1ml注入玻璃体腔内造成PVR模型。用兔眼玻璃体内注射药物的方法观察肝素对限内纤维增生的抑制作用及肝素的毒性。结果表明:肝素对防治增生性玻璃体现网膜病变有效,玻璃体内注射肝素100IU和50IU对眼部无毒性。本研究为肝素应用于临床提供了依据。
This study aimed to investigate the efficacy and toxicity of heparin on experimental proliferative vitreoretinopathy (PVR). Infusion with 0.1ml of fresh rabbit blood into the vitreous cavity PVR model. Rabbit intravitreal injection of drugs to observe the inhibition of heparin fibrillation within limits and heparin toxicity. The results showed that: Heparin on the prevention and treatment of proliferative vitreous appear omentum lesions effective intravitreal injection of heparin 100IU and 50IU non-toxic to the eye. This study provides a basis for the clinical application of heparin.