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目的:介入治疗中晚期头颈部恶性肿瘤的疗效评价和不良反应的处理。方法:近5年收治27例中晚期头颈部恶性肿瘤进行介入治疗,其中11例进行化疗药物局部动脉灌注+栓塞治疗2次,13例进行化疗药物局部动脉灌注+栓塞治疗3次,1例进行单纯化疗药物灌注3次,2例进行单纯化疗药物灌注1次,灌注的化疗药物为PDD(60～80)mg、5-Fu 1.0;栓塞剂为明胶海绵或栓塞微球。结果:2例患者行一次介入治疗,其余25例行(2～3)次介入治疗,介入治疗后患者症状均有不同程度的缓解。经局部动脉灌注+栓塞治疗的患者效果明显优于单纯灌注的患者。结论:对于中晚期头颈部恶性肿瘤进行局部动脉灌注+栓塞治疗或单纯化疗药物灌注的介入治疗,在缓解患者的临床症状方面是有效的。在治疗过程中出现的各种并发症不容忽视,应积极对症处理。
Objective: To evaluate the curative effect and adverse reaction of advanced head and neck malignant tumor by interventional therapy. Methods: Twenty-seven patients with advanced head and neck cancer were treated in the recent 5 years. Eleven patients underwent local arterial infusion and embolization of chemotherapy drugs and 13 patients underwent local arterial infusion and embolization of chemotherapy drugs for 3 times. One patient The patients were treated with chemotherapeutic drugs three times. Two patients were treated with chemotherapy alone. The chemotherapeutic drugs were PDD (60-80 mg) and 5-Fu 1.0. The embolic agent was gelatin sponge or embolized microspheres. Results: Two patients were treated with one intervention and the remaining 25 patients were treated with two or three interventions. The symptoms of patients were relieved to varying degrees after interventional therapy. The effect of local arterial infusion + embolization is better than that of simple perfusion. Conclusion: The interventional therapy of local arterial perfusion and embolization or simple chemotherapy drug infusion for advanced head and neck malignant tumors is effective in relieving the clinical symptoms of patients. In the course of treatment of various complications can not be ignored, should be symptomatic treatment.