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目的：研究阿霉素脂质体－碘油犬肝动脉栓塞后阿霉素的体内靶向性特征和药代动力学．方法：用高效液相色谱法（ＨＰＬＣ）测定犬血浆和肝组织中阿霉素的浓度．结果：阿霉素脂质体－碘油栓塞组犬血浆阿霉素浓度显著低于阿霉素溶液灌注组（Ｐ＜０．０１）和阿霉素－碘油栓塞组（Ｐ＜０．０５），而其血浆阿霉素消除半衰期和肝组织中阿霉素浓度与后两组相比则显著增加（Ｐ＜０．０１，Ｐ＜０．０５）．结论：阿霉素脂质体与碘油混合肝动脉栓塞后可显著提高阿霉素对肝脏的靶向性，延长阿霉素消除半衰期
OBJECTIVE: To study the in vivo targeting and pharmacokinetics of doxorubicin after adriamycin-liposome-lipiodol hepatic artery embolization. Methods: The concentration of doxorubicin in plasma and liver of dogs was determined by high performance liquid chromatography (HPLC). Results: The doxorubicin concentration of doxorubicin-lipiodol embolization group was significantly lower than that of doxorubicin solution perfusion group and doxorubicin-lipiodol embolization group (P <0.05) ), But its plasma half-life of doxorubicin and doxorubicin in liver tissue were significantly increased compared with the latter two groups (P <0.01, P <0.05). Conclusion: Adriamycin liposome mixed with lipiodol can obviously improve the targeting of doxorubicin to liver and prolong the elimination half-life of doxorubicin