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三阴性乳腺癌( TNBC)是雌激素受体、孕激素受体以及人表皮生长因子受体均为阴性的乳腺癌。相对于其他乳腺癌亚型，其具有侵袭性强、恶性程度高、患者预后差、辅助治疗后复发转移率高等特点。 TNBC对化疗较为敏感，治疗仍以细胞毒性药物为主。近年来，随着肿瘤分子生物学研究的深入，分子靶向治疗成为近几年乳腺癌研究和关注的焦点。该文就TNBC的治疗进展作一综述。“,”The estrogen receptor, progesterone receptor and human epidermal growth factor receptor of triple negative breast cancer (TNBC) are negative. Compared to other breast cancer subtypes,TNBC has strong invasiveness,high degree of malignancy and poor prognosis,with high recurrence rate after adjuvant therapy. TNBC is more sensitive to chemotherapy,and cytotoxic drugs are the main drugs. In recent years, with the increasing depth study of tumor molecular biology,molecular targeted therapy for breast cancer has become the focus,and here is to make a review of the treatment advances of TNBC.