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目的应用新生儿足跟血TSH水平了解我省碘营养状况。方法采集新生儿出生72h经6次以上母乳喂养的新生儿足跟血,让血液自然流出滴于s&s903专用滤纸上,渗透正反二面,室温下自然干燥后,采用时间分辨镧系荧光免疫分析法(DELFIA)检测甲状腺素(TSH)浓度。结果 1999-2007年305847例新生儿足跟血TSH水平的均值波动在1.8-2.58mIU/L、中位数波动在1.41-2.03mIU/L、P97波动在5.96-6.77mIU/L、TSH>5mIU/L的比例波动在4.11-8.98%。结论我省1997-2007年TSH>5mIU/L的比率均高于国际组织推荐的标准。
Objective To understand the iodine nutrition status of our province by using the heel blood TSH level of neonates. Methods The heel blood of newborn infants born more than six times at 72 h after birth was collected. The blood was naturally dropped on special filter paper of s & s 903, infiltrated on both sides, and then dried naturally at room temperature. The time-resolved Lanthanide fluorescence immunoassay Method (DELFIA) test thyroxine (TSH) concentration. Results The mean hematocrit TSH level of 305,847 newborns from 1999 to 2007 ranged from 1.8-2.58mIU / L with a median fluctuation of 1.41-2.03mIU / L, P97 fluctuations of 5.96-6.77mIU / L and TSH> 5mIU / L ratio fluctuations in the 4.11-8.98%. Conclusion The ratio of TSH> 5mIU / L from 1997 to 2007 in our province is higher than the standard recommended by international organizations.