1984年起,在泰国采用甲氟喹治疗无并发症的恶性疟。为了延缓抗性产生,开始时和磺胺多辛、乙胺嘧啶联合用药。当时现场甲氟喹单剂15mg/kg的治愈率近100％。鉴于当地恶性疟原虫对上述联合用的两药的敏感性较低,柬埔寨移民治疗服务中心于1990年7月改为单用甲氟喹治疗,1年后治愈率仅 Since 1984, mefloquine has been used in Thailand to treat uncomplicated falciparum malaria. In order to delay the generation of resistance, the beginning and sulfadoxine, pyrimethamine combination therapy. At that time on the scene mefloquine single 15mg / kg cure rate of nearly 100%. In view of the low sensitivity of the local Plasmodium falciparum to these two drugs in combination, the Cambodian Immigrant Treatment Service changed to mefloquine alone in July 1990 and the cure rate after only one year