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目的分析慢性阻塞性肺病合并心力衰竭患者测定降钙素原的早期诊断价值及临床意义。方法选取佛山市顺德区龙江医院2014年6月-2016年6月收治的慢性阻塞性肺病合并心力衰竭患者(慢阻肺合并心衰组)、单纯心力衰竭患者(单纯心力衰竭组)、健康志愿者(健康志愿者组)各80例为研究对象。结果慢阻肺合并心衰组降钙素值显著高于单纯心力衰竭组和健康志愿者组,差异有统计学意义(P<0.05);慢阻肺合并心衰组感染者革兰阴性菌与革兰阳性菌所含降钙素比较,革兰阴性菌组高于革兰阳性菌,差异有统计学意义(P<0.05)。结论降钙素在慢性阻塞性肺疾病合并心力衰竭早期诊断有助于纠正患者的心力衰竭,有利于进行早期抗感染治疗,防止抗生素的滥用,应用价值高,值得在临床上推广使用。
Objective To analyze the early diagnostic value and clinical significance of procalcitonin in patients with chronic obstructive pulmonary disease and heart failure. Methods Patients with chronic obstructive pulmonary disease (chronic obstructive pulmonary disease and heart failure group), patients with simple heart failure (heart failure group) and healthy subjects with chronic obstructive pulmonary disease (HFMD) were selected from Longjiang Hospital of Shunde District, Foshan City from June 2014 to June 2016, Volunteers (healthy volunteer group) of 80 cases for the study. Results The serum calcitonin in chronic obstructive pulmonary disease group was significantly higher than those in pure heart failure group and healthy volunteers (P <0.05). Gram-negative bacteria with COPD and heart failure group were significantly associated with Gram-positive bacteria contained calcitonin, Gram-negative bacteria group was higher than Gram-positive bacteria, the difference was statistically significant (P <0.05). Conclusion Calcitonin in the early diagnosis of chronic obstructive pulmonary disease combined with heart failure can help to correct heart failure patients, is conducive to early anti-infective treatment, to prevent the abuse of antibiotics, high value, it is worth to promote the clinical use.