目的:研究口腔黏膜白斑癌变和发病部位及临床表现的关系。方法:对15年来诊治的150例临床和组织学确诊为口腔白斑的病例进行回顾性分析。结果:龈、舌、颊等部位为白斑高发区,其中有14例白斑癌变,癌变率为9.33%。结论:口腔白斑以颗粒型、溃疡型、疣状型癌变率较高。癌变高发部位为舌部,舌部又以舌侧缘(包括舌腹和舌缘)的癌变率为著。 Objective: To study the relationship between the pathogenesis of oral leukoplakia and its clinical manifestations. Methods: A retrospective analysis of 150 clinically and histologically confirmed cases of oral leukoplakia was performed in 15 years. Results: The gingiva, tongue and cheeks were the high incidence area of ​​white spot, of which 14 cases were white spot canceration with the rate of 9.33%. Conclusion: Oral leukoplakia with granular type, ulcerative type, verrucous type cancer rate higher. Cancer high incidence of parts of the tongue, tongue and tongue edge (including the tongue and tongue margin) as the rate of cancer.