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曼氏血吸虫（Ｓｃｈｉｓｔｏｓｏｍａｍａｎｓｏｎｉ）和日本血吸虫（Ｓ．ｊａｐｏｎｉｃｕｍ）成虫和曼氏血吸虫尾蚴基因组ＤＮＡ经限制性内切酶ＢａｍＨＩ消化后，分别与３２ｐ─ｄＣＴＰ标记的来源于核糖体ＤＮＡ的ｐｓＭＨＣＲ５，ｐＳＭＨＣＲ４ＰＳＭ８８９探针杂交。曼氏血吸虫尾蚴和成虫在ｐＳＭＨＣＲ４杂交带型的１．６─２．８ｋｂ之间，存在有明显不同的次杂交带；而ｐＳＭＨＣＲ５和ｐＳＭ８８９的杂交带型，无明显差异。此外，ｐＳＭＨＣＲ５杂交带型中，日本血吸虫成虫无３．０ｋｂ带，可明显区别于曼氏血吸虫。结果表明，在曼氏血吸虫尾蚴至成虫的发育过程中，基因组ＤＮＡ发生缺失或重组。这一发现进一步证实了曼氏血吸虫毛蚴与成虫间存在发育期特异性ＤＮＡ的假设。曼氏血吸虫发育过程中，基因组ＤＮＡ的动态变化可能与其适应环境有关。
Schistosomamansoni and S. japonicum adults and Schistosoma mansoni cercariae genomic DNA were digested with restriction enzyme BamHI and ligated with 32p-dCTP-labeled ribosomal DNA-derived psMHCR5, pSMHCR4PSM889 probe Hybridization. Schistosoma mansoni cercariae and adults in the pSMHCR4 hybrid band between 1.6 ─ 2.8kb, there are significantly different secondary hybridization band; and pSMHCR5 and pSM889 hybridization band, no significant difference. In addition, pSMHCR5 hybridization band, the Japanese schistosome adult 3.0kb band, can be significantly different from Schistosoma mansoni. The results showed that during the development of Schistosoma mansoni cercariae to adults, the genomic DNA was deleted or recombined. This finding further confirms the hypothesis that there is developmental-specific DNA between Schistosoma mansoni and mirids. During the development of Schistosoma mansoni, the dynamic changes of genomic DNA may be related to its adaptation to the environment.