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目的 观察温热疗法结合化疗对小鼠 S180肿瘤协同治疗效果。 方法 4 5只 S180荷瘤小鼠随机分 3组 :热疗 +化疗组 ,单纯化疗组 ,单纯热疗组。每组 15只。处理后 10日处死动物 ,分离瘤块称湿重 ,并作病理检查。 结果 各组肿瘤湿重各为 (0 .6 7± 0 .2 9)克、(0 .78± 0 .37)克和 (1.2 4± 0 .4 3)克 ,热疗 +化疗组肿瘤湿重低于其余两组 ,其与单纯热疗组比较有显著差异 (P<0 .0 1)。病理检查见热疗 +化疗组及热疗组肿瘤存在明显坏死。 结论 实验结果提示热疗、化疗双因子联合应用具有更好的抗癌效果。
Objective To observe the effect of combination of thermotherapy and chemotherapy on S180 tumor in mice. Methods 4 5 S180 tumor-bearing mice were randomly divided into 3 groups: hyperthermia + chemotherapy group, chemotherapy alone group, hyperthermia group alone. 15 in each group Animals were sacrificed 10 days after treatment, the tumor mass isolated wet weight, and for pathological examination. Results The wet weight of each group was (0.67 ± 0.29) g, (0.78 ± 0.37) g and (1.2 4 ± 0.43) g, respectively. The hyperthermia + chemotherapy group Which was significantly lower than the other two groups (P <0.01). Pathological examination, see hyperthermia + chemotherapy group and hyperthermia group there is a clear tumor necrosis. Conclusion The experimental results suggest that the combination of two factors of hyperthermia and chemotherapy has better anticancer effect.