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本研究为探讨在慢性肾衰晚期患者中一氧化氮(NO)与内皮素(ET_1)水钠代谢的作用机制,分别应用分光光度比色法,放免法检测尿毒症患者尿中NO、ET_1水平,并测定了尿钠(UNa~+)。结果表明:①患者尿毒症期,终末期NO和ET_1水平与正常人相比有显著差异(P<0.05),ET_1在尿毒症期合成增加,终末期减少,而NO在此两期均降低;②NO与ET_1在尿毒症期呈负相关,提示尿毒症期NO亦抑制ET_1的产生,NO对ET_1可能具有负反馈调节作用;③NO与UNa~+、尿量(Uv)在两期均呈正相关,亦提示NO具有利尿、排钠的作用。
The purpose of this study was to investigate the mechanism of nitric oxide (NO) and endothelin (ET 1) sodium and sodium metabolism in patients with advanced renal failure. Spectrophotometry and radioimmunoassay were used respectively to detect the levels of NO and ET 1 in uremic patients , And urine sodium (UNa ~ +) was measured. The results showed that: (1) The levels of NO and ET - 1 in uremia and end - stage patients were significantly different from those in normal subjects (P <0.05); ET - 1 increased in uremia stage and decreased in terminal stage, while NO decreased in both stages; NO and ET_1 were negatively correlated with uremia, suggesting that NO also inhibits the production of ET_1 during uremia, and NO may have a negative feedback regulation on ET_1; ③NO and UNa ~ + and urine output (Uv) Also suggest that NO has diuretic, sodium role.