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目的评价介入治疗(TACE)和介入治疗加无水酒精注射治疗PEI(TACE+PEI)方式对肝癌的治疗效果。方法采用Logistic回归模型计算肝癌病人的倾向指数,然后按照倾向指数进行组间卡钳匹配,对匹配后的数据进行生存分析。结果匹配前两组的生存曲线差异无统计学意义(P=0.1),匹配后差异有统计学意义(P=0.0)。结论(1)介入治疗加无水酒精注射治疗对肝癌的治疗效果优于单纯的介入治疗方式。(2)倾向指数匹配法能有效的降低混杂偏倚,对肝癌的治疗效果做出正确评价。
Objective To evaluate the therapeutic effect of interventional therapy (TACE) and interventional therapy plus anhydrous alcohol injection on PEI (TACE + PEI) for liver cancer. Methods The Logistic regression model was used to calculate the propensity index of patients with hepatocellular carcinoma. Then the inter-group calipers were matched according to the propensity index, and the matched data were analyzed for survival. Results There was no significant difference in survival curves between the two groups before matching (P = 0.1), and the difference was statistically significant after matching (P = 0.0). Conclusion (1) Interventional therapy plus anhydrous alcohol injection is superior to simple interventional therapy in the treatment of liver cancer. (2) propensity index matching method can effectively reduce the hybrid bias, the correct evaluation of the treatment of liver cancer.