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目的:观察手术后应用吲哚美辛栓对胃肠道肿瘤病人免疫功能的影响。方法:将42例胃癌和结肠癌病人随机分为吲哚美辛组(22例)和对照组(20例)。两组病人行根治性手术治疗后24 h给予肠外营养支持7 d。吲哚美辛组术后每24 h给予吲哚美辛栓100 mg,对照组给予安慰剂。分别测定治疗前后病人外周血淋巴细胞总数、T细胞亚群(CD3+,CD4+,CD8+、CD4+/CD8+比值)和NK细胞活性。结果:两组病人术后第1天CD3+、CD4+和CD4+/CD8+比值、外周血淋巴细胞总数和NK细胞活性较术前均有所下降。术后第8天两组病人CD3+、CD4+、CD4+/CD8+比值、外周血淋巴细胞总数和NK细胞活性均有所改善。两组间比较,吲哚美辛栓组术后免疫功能改善更为明显,各项指标均优于对照组(P<0.05)。结论:胃肠道肿瘤病人术后应用吲哚美辛栓可改善细胞免疫功能。
Objective: To observe the effect of indometacin suppository on immune function in patients with gastrointestinal cancer after operation. Methods: Forty-two patients with gastric cancer and colon cancer were randomly divided into indometacin group (n = 22) and control group (n = 20). Two groups of patients were given parenteral nutrition 24 h after radical surgery for 7 days. The indometacin group was given indometacin suppository 100 mg every 24 hours after operation, and the control group was given placebo. The total number of peripheral blood lymphocytes, T cell subsets (CD3 +, CD4 +, CD8 +, CD4 + / CD8 + ratio) and NK cell activity were measured before and after treatment. Results: On the first day after operation, the ratio of CD3 +, CD4 + and CD4 + / CD8 +, the total number of peripheral blood lymphocytes and NK cell activity decreased in both groups. On the 8th day after operation, the ratio of CD3 +, CD4 +, CD4 + / CD8 +, total number of peripheral blood lymphocytes and NK cell activity in both groups were improved. Compared with the control group, the indometacin suppository group showed more obvious improvement in the immune function after operation, and all indexes were better than the control group (P <0.05). Conclusion: Indometacin suppository can improve cellular immune function in patients with gastrointestinal cancer after operation.