论文部分内容阅读
目的观察早期再灌注治疗对急性心肌梗死(AMI)左室室壁瘤形成的逆转效应及心功能改善作用。方法选取发病12h以内急性前壁心肌梗死伴室壁瘤形成患者,随机分为经皮冠状动脉介入治疗(PCI)组、溶栓组及常规药物治疗组;三组患者均在治疗后1、24w分别行超声心动图(UCG)和平衡法核素心室造影(ERNA),评价左室质量指数(LVMI)和局部室壁运动积分(RWMI)、心室收缩同步性(VSS)和心功能(HF)参数改善状况。结果治疗后1w和24w时,PCI组RWMI、VSS和HF均优于溶栓组和常规药物治疗组(P均<005)。PCI组和溶栓组24w时上述各参数均优于1w。常规药物治疗组VSS参数中相角程(PS)在24w时较1w有所改善,余各项结果比较无显著性差异。结论PCI组和溶栓组均可阻抑室壁瘤形成及改善心功能,且PCI优于溶栓治疗。
Objective To observe the reversal effect of early reperfusion therapy on the formation of left ventricular aneurysm (AMI) and the improvement of cardiac function in patients with acute myocardial infarction (AMI). Methods Acute anterior myocardial infarction with aneurysm formation within 12 hours after onset was selected and randomly divided into percutaneous coronary intervention (PCI) group, thrombolytic group and conventional drug treatment group. The three groups of patients were treated with 1,24w The left ventricular mass index (LVMI), regional wall motion score (RWMI), left ventricular systolic synchrony (VSS), and cardiac function (HF) were evaluated by echocardiography (UCG) and balanced radionuclide ventriculography (ERNA) Parameters to improve the situation. Results At 1w and 24w after treatment, RWMI, VSS and HF in PCI group were better than those in thrombolytic group and conventional drug treatment group (all P <0.05). PCI and thrombolysis group 24w when the above parameters are better than 1w. The phase angle (PS) of the VSS parameters in the conventional drug treatment group was better than 1w at 24w, and there was no significant difference among the results. Conclusion Both PCI group and thrombolytic group can inhibit the formation of aneurysm and improve cardiac function, and PCI is better than thrombolytic therapy.