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目的了解中国(未包括香港、澳门特别行政区和台湾地区,下同)2010年<15岁儿童吉兰-巴雷综合征(Guillian-Barré Syndrome,GBS)的流行病学特征、临床表现、实验室检测结果和麻痹残留情况,并探索影响GBS预后的因素。方法对中国2010年免疫规划监测信息管理系统中,<15岁儿童急性弛缓性麻痹(Acute Flaccid Paralysis,AFP)病例个案数据进行分析。结果中国2010年AFP病例监测系统共报告<15岁儿童GBS1033例,报告发病率为0.42/10万。上、下肢均发生麻痹、严重麻痹和粪便标本中分离出非脊髓灰质炎肠道病毒(Non-polio Enterovirus,NPEV)的GBS预后较差。结论 GBS在中国2010年<15岁儿童AFP病例中占居首位,有必要加强对GBS的管理,尤其是上、下肢均发生麻痹、严重麻痹和NPEV阳性的病例。
Objective To understand the epidemiological characteristics, clinical manifestations and laboratory of Guillian-Barre Syndrome (GBS) in China (excluding Hong Kong SAR, Macao SAR and Taiwan region, the same below) Test results and residual paralysis, and explore the factors that affect the prognosis of GBS. Methods The case data of Acute Flaccid Paralysis (AFP) cases in children aged <15 years were analyzed in China’s 2010 immunization program monitoring information management system. Results The AFP case surveillance system in China reported a total of 1033 cases of GBS in 15-year-old children in 2010, with a reported incidence of 0.42 / 100,000. Paralysis of the upper and lower limbs occurred. Severe paralysis and poor prognosis of GBS isolated from non-polio enterovirus (NPEV) in stool specimens were poor. Conclusions GBS occupies the first place in AFP cases of children aged <15 years in China in 2010, and it is necessary to strengthen the management of GBS, especially the paralysis, serious paralysis and NPEV positive cases in both upper and lower limbs.