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晚近研究表明妊娠和乳癌患者常出现一种罕见的触珠蛋白。这种蛋白与触珠蛋白相关蛋白(Hpr)有相同的抗原决定簇。肿瘤细胞中Hpr决定簇的表达可能与肿瘤的临床行为有关。作者对1977～1985年间70例因早期(Ⅰ期或Ⅱ期)乳癌行乳房切除的浸蜡标本用免疫组化法进行回顾性研究,通过肿瘤组织中Hpr决定簇、孕激素受体、雌激素受体、肿瘤大小、临床分期、腋下淋巴结状况、有丝分裂指数和肿瘤坏死等指标来预测肿瘤复发。寿命表分析表明Hpr表达与近期复发有
Recent studies have shown that rare haptoglobin often occurs in patients with pregnancy and breast cancer. This protein has the same antigenic determinants as the haptoglobin-related protein (Hpr). The expression of Hpr determinants in tumor cells may be related to the clinical behavior of the tumor. The authors retrospectively studied 70 cases of immersion wax specimens for mastectomy with early (stage I or stage II) breast cancer from 1977 to 1985 by Hp determinants, progesterone receptors, and estrogens in the tumor tissues. Receptors, tumor size, clinical stage, axillary lymph node status, mitotic index and tumor necrosis were used to predict tumor recurrence. Life Table Analysis Shows Hpr Expression and Recent Relapse