设计并合成了5种具有胆酸单元的氢化烟酰胺腺嘌呤二核苷酸(NADH)模型化合物,并以苯甲酰甲酸甲酯为底物,镁离子为催化剂,研究了模型化合物的不对称还原能力.结果表明这些模型化合物能够将α-酮酸酯还原为α-羟基酸酯,有一定的负氢转移能力,但它们的手性还原能力不佳,对映体过量值最高为26%. Five hydrogenated nicotinamide adenine dinucleotide (NADH) model compounds with cholic acid units were designed and synthesized. The asymmetric structure of the model compounds was studied by using methyl benzoylformate as substrate and magnesium as catalyst Reduction ability.The results show that these model compounds can reduce α-ketoester to α-hydroxy acid ester, have a certain negative hydrogen transfer ability, but their chiral reduction ability is poor, the enantiomeric excess is up to 26% .