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鲍姆氏层孔菌Phellinus baumii子实体中分离得到的化合物,通过波谱分析,分别鉴定为:麦角甾‐7,22‐二烯‐3β‐醇十五烷酸酯(1),星鱼甾醇(2),灵芝醇B(3),麦角甾‐6,22‐二烯‐3β,5α,8α‐三醇(4),灵芝酸DM(5)和Inoscavin A(6)。化合物1、2、3、4、5为首次从Phellinus baumii子实体中获得。对化合物进一步作了体外抗肿瘤实验,结果表明,化合物1、2、4、5、6对肿瘤细胞K562的增殖有不用程度的抑制作用,其抑制率IC50值分别为63.5、10.3、70.6、35.9和3.5μg/m L。化合物5对肿瘤细胞Hep G2也有明显的抑制作用,其抑制率IC50值为50.3μg/m L。
Compounds isolated from the fruiting body of Phellinus baumii were identified by spectroscopic analysis as ergosta-7,22-dien-3β-olpentadecanoate (1), starfish sterol 2), gliadin B (3), ergosta-6,22-diene-3β, 5α, 8α-triol (4), ganoderic acid DM (5) and Inoscavin A (6). Compounds 1,2,3,4,5 were obtained from Phellinus baumii fruiting bodies for the first time. The compounds were further in vitro antitumor experiments, the results showed that the compounds 1,2,4,5,6 on the proliferation of K562 tumor cells with a degree of inhibition, the IC50 values were 63.5,10.3,70.6,35.9 And 3.5 μg / m L. Compound 5 also significantly inhibited Hep G2 tumor cells with an IC50 value of 50.3 μg / m L.