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应用免疫组织化学定量分析的方法，对１２例胰岛素非依赖型糖尿病（ＮＩＤＤＭ）肾病患者肾活检组织中胰岛素样生长因子－１（ＩＧＦ－１）受体、表皮生长因子（ＥＧＦ）和表皮生长因子受体（ＥＧＦ－Ｒ）进行了观察，并结合患者的病程、糖尿病肾病分期和肾功能进行了比较。ＮＩＤＤＭ肾病患者肾小管上ＥＧＦ和ＥＧＦ－Ｒ的量明显高于正常人，部分患者肾小球ＥＧＦ也呈阳性反应。正常人和ＮＩＤＤＭ肾病患者肾小管上ＩＧＦ－１受体的量则无明显差异。提示肾小管上ＥＧＦ和ＥＧＦ－Ｒ含量增加可能参与ＮＩＤＤＭ肾病的发病过程，而肾小球内ＥＧＦ的出现与系膜细胞和系膜基质增生有关。
Immunohistochemistry was used to detect the expression of insulin-like growth factor-1 (IGF-1) receptor, epidermal growth factor (EGF) and epidermal growth factor (EGF) in renal biopsies from 12 patients with NIDDM Receptor (EGF-R) was observed and compared with the patient’s course, diabetic nephropathy staging and renal function. The amount of EGF and EGF-R in renal tubules of patients with NIDDM nephropathy was significantly higher than that in normal people, and glomerular EGF was also positive in some patients. There was no significant difference in the amount of IGF-1 receptor in renal tubules between normal and NIDDM nephropathy patients. It is suggested that the increase of EGF and EGF-R in the tubules may be involved in the pathogenesis of NIDDM nephropathy, while the occurrence of glomerular EGF is related to the proliferation of mesangial cells and mesangial matrix.