论文部分内容阅读
目的:观察银杏叶片治疗特发性肺间质纤维化的临床效果,并探讨其相关的作用机制。方法:选取60例特发性肺间质纤维化患者,依据随机数字表法分为对照组和治疗组各30例。对照组给予常规治疗,治疗组在常规治疗的基础上加服银杏叶片,疗程为12周,比较2组的疗效。采用酶联免疫吸附法(ELISA)分别检测2组患者治疗前后血清中的转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)和基质金属蛋白酶-9(MMP-9)的表达水平。结果:对照组总有效率为60.00%,治疗组总有效率为83.33%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组TGF-β1、TNF-α和MMP-9的表达水平均较治疗前下降(P<0.05,P<0.01);与对照组相比,治疗组3项细胞因子的表达水平均下降,差异均有统计学意义(P<0.05)。结论:银杏叶片治疗特发性肺间质纤维化具有良好的疗效,其作用机理可能与下调TGF-β1、TNF-α和MMP-9表达水平有关。
Objective: To observe the clinical effect of Ginkgo biloba leaf on the treatment of idiopathic pulmonary fibrosis and to explore its related mechanism. Methods: Sixty patients with idiopathic pulmonary fibrosis were selected and divided into control group and treatment group according to random number table. The control group was given conventional treatment. The treatment group was given ginkgo leaf on the basis of routine treatment, the course of treatment was 12 weeks. The curative effect of the two groups was compared. Serum levels of TGF-β1, TNF-α and MMP-9 were measured by enzyme-linked immunosorbent assay (ELISA) ) Expression level. Results: The total effective rate in the control group was 60.00%, and the total effective rate in the treatment group was 83.33%. There was significant difference between the two groups (P <0.05). After treatment, the expression levels of TGF-β1, TNF-α and MMP-9 in the two groups were significantly lower than those before treatment (P <0.05, P <0.01); compared with the control group, the expression levels of three cytokines Decreased, the differences were statistically significant (P <0.05). CONCLUSION: Ginkgo biloba leaves have a good therapeutic effect on idiopathic pulmonary fibrosis. The mechanism may be related to down-regulating the expression of TGF-β1, TNF-α and MMP-9.