远在二千多年前,祖国医学对时间因素在疾病的发生、发展和治疗中的重要意义,就有很多论述,例如中医经典著作《黄帝内经》就曾明确指出“圣人之治病也,必知天地阴阳、四时纲纪”,即是说治病用药必须注意气候、时令等因素的影响。到了五十年代初期,终于诞生了时间药理学(Chrooopbarmacology)这一新兴学科,它是介于时间生物学和药理学间的 As far as more than two thousand years ago, there was a lot of discussion about the importance of time factors in the occurrence, development and treatment of diseases in the motherland’s motherland. For example, the classic Huang Di Nei Jing, a traditional Chinese medicine book, Must know the world yin and yang, Si Shigang Ji ", that is, the treatment of medication must pay attention to climate, seasonal and other factors. By the early fifties, the emerging discipline of Chrooopbarmacology was finally born, which is between time biology and pharmacology