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目的:探讨尿毒症患者发生抗生素脑病的原因,提高抗生素脑病的防治水平。方法:回顾性分析23例出现抗生素脑病的住院尿毒症患—104—者的临床资料。结果:23例患者在使用抗生素2~7天后出现神经精神症状,其中头孢他啶7例,头孢吡肟4例,头孢哌酮/舒巴坦4例,左氧氟沙星3例,头孢替唑钠3例,阿昔洛韦2例。予停药加强对症治疗,以及血滤血灌后缓解。结论:对于应用抗生素的尿毒症患者,严格掌握指征,根据肾小球滤过率减量使用或延长给药间期,调整透析方式。
Objective: To investigate the causes of antibiotic encephalopathy in uremic patients and to improve the prevention and cure of antibiotic encephalopathy. Methods: A retrospective analysis of 23 cases of antibiotic encephalopathy hospitalized uremic -104- clinical data. Results: Neuropsychiatric symptoms occurred in 23 patients 2 to 7 days after antibiotics were administered, of which 7 were ceftazidime, 4 were cefepime, 4 were cefoperazone / sulbactam, 3 were levofloxacin and 3 were ceftezole sodium. Cyclocarb in 2 cases. To stop treatment to enhance symptomatic treatment, and blood reperfusion after reperfusion. Conclusion: For patients with uremia using antibiotics, strict indications, according to glomerular filtration rate reduction or prolonged use of drug delivery interval, adjusting the mode of dialysis.