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目的了解MRSA医院感染的情况,分析引起感染的危险因素及细菌的抗生素耐药谱。方法于2012年1月～2012年5月在本院收集分离出的不重复金黄色葡萄球菌,对分离出来的金黄色葡萄球菌进行抗生素药敏试验。采用自行设计调查表,收集患者在金黄色葡萄球菌检出前病案资料,分析其危险因素。结果分离的83株金黄色葡萄球菌,33株(39.8%)为MRSA,红霉素、克林霉素、庆大霉素、环丙沙星及复方新诺明在MRSA菌株的耐药情况更为严重(P值分别为0.009,0.006,0.018,0.021,0.022)。多元logistic回归分析显示,住院时间超过10d、至少使用3种抗生素、深静脉插管、一年前曾经住院、住院时有皮肤软组织感染、住院时发生菌血症、住院时有呼吸衰竭为MRSA感染的危险因素(OR值分别为5.397,6.416,5.576,6.926,14.805,16.462,12.566)。结论金黄色葡萄球菌多药耐药情况严重,MRSA感染因素多,原因复杂,应主动监测金黄色葡萄球菌感染情况。
Objective To understand the situation of MRSA nosocomial infection and analyze the risk factors of infection and antibiotic resistance spectrum of bacteria. Methods From January 2012 to May 2012, the isolated unrepeated Staphylococcus aureus was collected in our hospital and the antibiotic susceptibility test was performed on the isolated Staphylococcus aureus. Using self-designed questionnaire to collect patients before the detection of Staphylococcus aureus case data to analyze the risk factors. Results 83 isolates of Staphylococcus aureus and 33 isolates (39.8%) were more resistant to MRSA than MRSA, erythromycin, clindamycin, gentamicin, ciprofloxacin and cotrimoxazole Serious (P values were 0.009,0.006,0.018,0.021,0.022). Multivariate logistic regression analysis showed that the hospital stay of more than 10 days, at least three kinds of antibiotics, deep vein catheterization, hospitalized a year ago, hospitalized with skin and soft tissue infections, bacteremia when hospitalized, respiratory failure when hospitalized for MRSA infection Risk factors (OR values were 5.397,6.416,5.576,6.926,14.805,16.462,12.566). Conclusion Staphylococcus aureus multidrug resistance is serious, MRSA infection factors, the reasons are complex, should take the initiative to monitor the situation of Staphylococcus aureus infection.