1896年Salmen首先在人体的胃粘膜上发现一种螺旋形的细菌,当时,对其意义未加阐明,直到1982年Marshall成功地培养出此菌,现命名为幽门弯曲菌。在胃镜检查的病人中,约40～60％发现此细菌。Koch’s认为,确定一种细菌为致病菌必需具备三点:①在病人中均可发现该菌,而且细菌的分布应与病灶一致;②在患者的体内培养出该细菌;③接种于易感者可发生疾病。许多 In 1896, Salmen first discovered a spiral-shaped bacterium in human gastric mucosa. At that time, its meaning was not clarified. Until 1982, Marshall successfully cultivated this bacterium and is now named Campylobacter pylori. In gastroscopy patients, about 40 ~ 60% of the bacteria found. Koch’s that the determination of a bacteria as a pathogen must have three points: ① can be found in patients with the bacteria, and the distribution of bacteria should be consistent with the lesion; ② in the patient’s body to cultivate the bacteria; ③ vaccination susceptible Can occur disease. a lot of