肿瘤蛋白为肿瘤生长所必需,因而是肿瘤疫苗的目标。然而,编码功能蛋白的基因疫苗可把癌基因引入正常细胞,导致注射部位癌细胞发生。 荷兰莱登大学研究人员研制的疫苗仅释放来源于肿瘤相关抗原的、必需的T细胞表位。他们证明,这种疫苗能保护小鼠防御致死性肿瘤攻击。此外,应用复制缺陷性重组腺病毒(rAd)较易大量生产疫苗。 Tumor proteins are required for tumor growth and are therefore the goal of tumor vaccines. However, gene vaccines that encode functional proteins can introduce oncogenes into normal cells, leading to cancer cells at the injection site. Vaccines developed by researchers at the University of Leiden in the Netherlands release only the necessary T-cell epitopes derived from tumor-associated antigens. They show that the vaccine protects mice against lethal tumor attacks. In addition, the use of replication-defective recombinant adenovirus (rAd) is easier to produce in large quantities.