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目的:探讨左氧氟沙星致不良反应发生的规律及特点,为临床合理用药提供参考。方法:通过中国知网(CNKI)的中国医院知识仓库(CHKD)期刊全文数据库及万方数据库检索到1999～2010年有关左氧氟沙星致不良反应的有效文献322篇,并按患者性别、年龄、原患疾病与过敏史、给药途径、累及器官或系统及临床表现等方面进行统计、分析。结果:收集左氧氟沙星所致不良反应296例,其中,248例(83.78%)通过静脉途径给药;不良反应以神经系统及全身性损害最多,有79例(26.35%);其发生时间最早的在用药1min内,最迟的在用药2个月后。结论:左氧氟沙星引起的不良反应临床表现复杂多样,其发生与多种因素有关,最严重的可能引起死亡,值得临床医师关注。
Objective: To investigate the regularity and characteristics of adverse reactions induced by levofloxacin and to provide reference for clinical rational drug use. Methods: A total of 322 valid articles about adverse reactions caused by levofloxacin from 1999 to 2010 were retrieved from Chinese Journal of Hospital Knowledge Warehouse (CHKD) full-text database and Wanfang database of China National Knowledge Infrastructure (CNKI). According to gender, age, History of disease and allergy, route of administration, involved organ or system and clinical manifestations, etc. Statistics and analysis. RESULTS: A total of 296 cases of levofloxacin-induced adverse reactions were obtained, of which 248 cases (83.78%) were administered by intravenous route. The adverse reactions were mostly caused by nervous system and systemic injury, with 79 cases (26.35%) having the most adverse reactions occurring at Medication within 1min, the latest in medication 2 months later. CONCLUSION: The clinical manifestations of adverse reactions caused by levofloxacin are complex and diverse. The occurrence of the levofloxacin is related to many factors. The most serious cause of death may be clinicians’ attention.