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目的:探讨血浆同型半胱氨酸(homocysteine,Hcy)浓度与脑梗死的相关性。方法:观察组选取135例脑梗死患者,对照组选取135例于门诊体检科进行健康检查的中老年人,以完全相同的方式检测两组对象血浆Hcy浓度和胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等指标。结果:观察组血浆Hcy浓度以及TC、TG和LDL-C等均显著高于对照组,差异有统计学意义(P<0.05),而两组间HDL-C差异无统计学意义(P>0.05)。观察组血浆Hcy浓度与临床神经功能缺损程度评分呈正相关,且血浆Hcy浓度在轻型组、中型组和重型组三组间差异有统计学意义(P<0.01)。结论:血浆Hcy浓度在脑梗死患者中显著增高,且与临床神经功能缺损程度评分呈正相关,可以作为脑梗死发病风险的预测指标。
Objective: To investigate the relationship between plasma homocysteine (Hcy) concentration and cerebral infarction. Methods: One hundred and thirty-five patients with cerebral infarction were selected in the observation group and 135 middle-aged and elderly patients in the control group were selected for health examination. The concentrations of plasma Hcy, cholesterol (TC), triglyceride TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and other indicators. Results: The plasma concentrations of Hcy, TC, TG and LDL-C in the observation group were significantly higher than those in the control group (P <0.05), but there was no significant difference in HDL-C between the two groups (P> 0.05 ). Plasma Hcy concentration in the observation group was positively correlated with the score of clinical neurological deficit, and plasma Hcy concentration was significantly different among the three groups (P <0.01). Conclusion: The plasma Hcy concentration is significantly increased in patients with cerebral infarction, and positively correlated with the score of clinical neurological deficit, which can be used as a predictor of the risk of cerebral infarction.