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目的:分析HBV感染孕妇肝特异性自身抗体的存在情况及其自身意义。方法:选取该科2011年6月~2014年6月HBV感染孕妇共80例作为研究对象,同时选取80例健康孕妇作为对照组。对比两组孕妇的自身抗体水平,同时对比感染HBV孕妇组中自身抗体阳性/阴性者肝功能、免疫球蛋白水平和HBV DNA阳性率。结果:感染HBV孕妇组的血清中自身抗体总阳性率为27.50%,显著高于正常孕妇组(3.75%),χ2=22.818 8,P<0.01。自身抗体阳性组患者的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、IgG、IgM和IgA水平均显著高于自身抗体阴性组,P<0.05。自身抗体阳性患者的HBV DNA阳性率显著高于自身抗体阴性患者,χ2=4.702 2,P<0.05。结论:HBV感染可能是引起孕妇自身免疫功能损害的机制之一,同时自身抗体阳性和肝功能受损及病毒活跃复制相关。
Objective: To analyze the existence of liver-specific autoantibodies in pregnant women with HBV infection and its own significance. Methods: A total of 80 pregnant women with HBV infection from June 2011 to June 2014 were selected as research subjects, and 80 healthy pregnant women were selected as control group. The level of autoantibodies was compared between two groups of pregnant women, and at the same time, the levels of liver function, immunoglobulin and HBV DNA positive rate of autoantibodies positive / negative in HBV infected pregnant women were compared. Results: The positive rate of autoantibodies in pregnant women infected with HBV was 27.50%, significantly higher than that in normal pregnant women (3.75%) (χ2 = 22.818 8, P <0.01). The levels of ALT, AST, IgG, IgM and IgA in autoantibody positive group were significantly higher than those in autoantibody negative group (P <0.05). The positive rate of HBV DNA in autoantibodies positive patients was significantly higher than that of autoantibodies (χ2 = 4.702 2, P <0.05). Conclusions: HBV infection may be one of the mechanisms that cause autoimmune dysfunction in pregnant women. At the same time, autoantibodies are associated with impaired liver function and active viral replication.