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目的:探讨肝细胞癌患者接受肝动脉栓塞联合射频消融治疗后早、晚期复发的危险因素。方法:选择2006年1月至2011年1月于首都医科大学附属北京佑安医院接受肝动脉栓塞联合射频消融治疗的肝细胞癌患者246例，收集其临床资料及随访数据，应用Cox单因素分析得出影响肝细胞癌患者肝动脉栓塞联合射频消融后早、晚期复发的影响因素；Cox回归多因素分析得出独立影响因素。结果:246例肝细胞癌患者进行肝动脉栓塞联合射频消融治疗，中位随访时间99个月，共有179例患者出现复发，67例患者无复发；以24个月为界，早期复发95例，晚期复发84例，1年、2年、3年、5年、10年复发率分别是21.3%、39.0%、53.0%、67.3%、77.6%。COX多因素回归分析显示，肿瘤最大径(n HR = 2.183, 95%n CI：1.414~3.369, n P < 0.01)和肿瘤数目( n HR = 1.681, 95%n CI：1.110~2.545，n P < 0.05)是肝细胞癌患者肝动脉栓塞联合射频消融治疗后早期复发的独立影响因素；肝硬化( n HR = 0.421，95%n CI：0.272~0.651, n P < 0.01)是肝细胞癌患者肝动脉栓塞联合射频消融治疗后晚期复发的独立影响因素。n 结论:肝细胞癌经肝动脉栓塞联合射频消融治疗后早期复发的独立影响因素是肿瘤直径和肿瘤数目，晚期复发的独立影响因素是肝硬化。“,”Objective:To investigate the risk factors for recurrence of early and late stage hepatocellular carcinoma after receiving hepatic artery embolization combined with radiofrequency ablation therapy.Methods:246 cases with hepatocellular carcinoma who underwent hepatic artery embolization combined with radiofrequency ablation in Beijing You\'an Hospital Affiliated to Capital Medical University from January 2006 to January 2011 were selected. Clinical and follow-up data were collected. Univariate Cox analyses was used to determine the factors influencing recurrence of early and late stage HCC after hepatic artery embolization combined with radiofrequencies ablation. Multivariate Cox regression analysis was used to determine the independent factors.Results:246 case with hepatocellular carcinoma were treated with hepatic artery embolization combined with radiofrequency ablation, with median follow-up time of 99 months. A total of 179 cases had recurrence and 67 cases had no recurrence. Considering 24 months as the limit, 95 cases had early recurrence and 84 cases had late recurrence. The 1-, 2-, 3-, 5-, and 10-year recurrence rates were 21.3%, 39.0%, 53.0%, 67.3%, and 77.6%, respectively. Multivariate Cox regression analysis showed that the maximum tumor diameter (n HR = 2.183, 95% n CI: 1.414-3.369, n P < 0.01) and tumor number ( n HR = 1.681, 95% n CI: 1.110-2.545, n P < 0.05) were independent factor influencing recurrence of early stage HCC after hepatic artery embolization combined with radiofrequency ablation. Liver cirrhosis ( n HR = 0.421, 95% n CI: 0.272-0.651, n P < 0.01) was an independent factor influencing recurrence of late stage HCC after hepatic artery embolization combined with radiofrequency ablation.n Conclusion:Tumor diameter and number are independent factors influencing recurrence of early stage HCC, while liver cirrhosis is an independent factor influencing recurrence of late stage HCC after hepatic artery embolization combined with radiofrequency ablation therapy.