In this paper, flow around two circular cylinders in tandem arrangement with unequal diameters has been investigated using the particle image velocimetry technique(PIV) in a water channel. The upstream to downstream diameter ratio was kept constant at d/D = 2/3, the centre-to-centre distance was varied from 1.2D to 5D and the Reynolds number was varied from 1200 to 4800. The flow characteristics were analyzed through ensemble-averaged patterns of velocity, vorticity, normalized Reynolds stress contours and streamlines. Based on ensemble-averaged and instantaneous flow fields, different flow patterns, including single-wakeshedding at small spacing ratio, bi-stable flow behavior(alternating behavior of reattachment and vortex shedding) at intermediate spacing ratio and co-shedding pattern at large spacing ratio were observed. The effects of Reynolds number and the centre-to-centre spacing ratio on flow patterns and turbulent characteristics were also investigated. It was found that the diameter ratio appears to have a certain effect on the flow patterns at intermediate spacing ratios, where the reattachment of shear layer depends on the lateral width of the wake flow in the lee of the upstream cylinder. Extensive discussion on the distributions of Reynolds stress and turbulent kinetic energy was presented. In this paper, flow around two circular cylinders in tandem arrangement with unequal diameters has been investigated using the particle image velocimetry technique (PIV) in a water channel. The upstream to downstream diameter ratio was kept constant at d / D = 2/3, the center-to-center distance was varied from 1.2D to 5D and the Reynolds number was varied from 1200 to 4800. The flow characteristics were analyzed through ensemble-averaged patterns of velocity, vorticity, normalized Reynolds stress contours and streamlines. Based on ensemble -averaged and instantaneous flow fields, different flow patterns, including single-wakeshedding at small spacing ratio, bi-stable flow behavior (alternating behavior of reattachment and vortex shedding) at intermediate spacing ratio and co-shedding pattern at large spacing ratio were observed. The effects of Reynolds number and the center-to-center spacing ratio on flow patterns and turbulent characteristics were also investigated. It was found that the d iameter ratio appears to have a certain effect on the flow patterns at intermediate spacing ratios, where the reattachment of shear layer depends on the lateral width of the wake flow in the lee of the upstream cylinder. Extensive discussion on the distributions of Reynolds stress and turbulent kinetic energy was presented.