胎儿发育缺陷需要进行宫内手术矫正时 ,由于手术同时涉及母亲和胎儿 ,手术、麻醉及早产等均可对母亲和胎儿造成危险 ,故美国国立卫生院 (ＮＩＨ)建议应用母胎手术代替以往的胎儿手术[1] 。1　母胎手术的历史[2 ]　　 196 3年 ,Ｌｉｌｅｙ等首次成功地对 1例Ｒｈ溶血所致严重贫 Fetal developmental defects require intrauterine surgical correction, due to surgery involving both mother and fetus, surgery, anesthesia and premature delivery can be dangerous to the mother and fetus, so the National Institutes of Health (NIH) recommended the use of maternal fetal surgery instead of the previous fetus Surgery [1]. 1 The history of maternal fetal surgery [2] 196 3 years, Liley and other first successful cases of Rh hemolysis due to severe severe