论文部分内容阅读
目的探讨紫杉醇与顺铂化疗(TP)联合深部热疗对局部晚期非小细胞肺癌的疗效及预后影响。方法选取88例局部晚期非小细胞肺癌患者为研究对象,将患者采用简单抽样法随机分成观察组(A组,45例)和对照组(B组,43例)。B组患者仅予以TP方案,A组患者则在上述基础上联合深部热疗。比较两组患者近期治疗效果及不良反应发生情况,随访1年,记录患者Karnofsky功能状态评分(KPS评分)。结果 A组患者总有效率、随访1年生存率均优于B组;A组患者生活质量改善率为77.8%,明显高于B组的51.2%,差异有统计学意义(P<0.05);A、B两组不良反应比较,差异无统计学意义(P>0.05)。结论对局部晚期非小细胞肺癌患者予以TP联合深部热疗方案,临床疗效明显。
Objective To investigate the efficacy and prognosis of paclitaxel combined with cisplatin chemotherapy (TP) combined with deep hyperthermia on locally advanced non-small cell lung cancer. Methods Eighty - eight patients with locally advanced non - small cell lung cancer were enrolled in this study. Patients were randomly divided into observation group (A group, 45 cases) and control group (B group, 43 cases) by simple sampling method. Patients in group B received only TP regimen while patients in group A received deep hyperthermia on the above basis. The recent treatment and adverse reactions were compared between the two groups. After one year of follow-up, Karnofsky functional status scores (KPS scores) were recorded. Results The total effective rate and the 1 - year follow - up survival rate of group A were better than that of group B. The improvement rate of quality of life in group A was 77.8%, which was significantly higher than that of group B (51.2%, P <0.05). A, B two groups of adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The combination of TP combined with deep hyperthermia in patients with locally advanced non-small cell lung cancer has obvious curative effect.