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获得性免疫缺陷综合征(简称艾滋病、AIDS)的潜伏病原至今还逃避处置。此病伴有T_4辅助/诱导淋巴细胞的选择性减少和并发免疫缺陷(机会性感染、Kaposi肉瘤或神经损害)。AIDS的病因已证明是一种外源性的C-型逆转录病毒,称为人免疫缺陷病毒(HIV)。本文将集中讨论对HIV感染和完全破坏AIDS的两种早期主要控制途径,首先是对HIV复制的特异性控制,其次为免疫的重建。在讨论抗病毒药和免疫调节的作用时,应考虑对免疫缺陷或发病前无症状的HIV携带者进行早期治疗的可能性。
The latent pathogen of Acquired Immune Deficiency Syndrome (AIDS, AIDS) has yet to evade treatment. The disease is associated with decreased selectivity for T 4 helper / induced lymphocytes and concurrent immunodeficiency (opportunistic infections, Kaposi’s sarcoma or nerve damage). The etiology of AIDS has turned out to be an exogenous C-type retrovirus called the human immunodeficiency virus (HIV). This article will focus on two early major control approaches to HIV infection and complete destruction of AIDS, starting with the specific control of HIV replication followed by immune reconstitution. In discussing the role of antiviral drugs and immune regulation, consideration should be given to the possibility of early treatment of immunodeficiency or asymptomatic HIV carriers before onset.