Ｗｉｓｔａｒ大鼠７５只分５组，分别灌饲阿司匹林６０，０，５，３０及６０ｍｇ／（ｋｇ．ｄ），除第１组外，周末每组大鼠注二甲基肼３０ｍｇ／ｋｇ，至１８周处死动物，取结肠沿长轴剖开，洗净，纪录病变部位，形态及直径。结果显示随阿司匹林剂量增加，结肠肿瘤数目减少；≥５ｍｍ肿瘤百分比降低（Ｐ＜０．０１）。表明阿司匹林可减少结肠癌形成。 Seventy-five Wistar rats were divided into 5 groups and were given aspirin 60,0,5,30 and 60 mg/(kg.d) respectively. Except for group 1, each group of rats received dimethyl hydrazine 30 mg/kg on weekends. The animals were sacrificed 18 weeks later. The colon was taken along the long axis and washed. The lesion site, shape and diameter were recorded. The results showed that as the aspirin dose increased, the number of colon tumors decreased; the percentage of tumors ≥5 mm decreased (P<0.01). Shows that aspirin can reduce the formation of colon cancer.