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Objective:Objective: To investigate the relationship of serum Myostatin content with lipid metabolism, insulin resistance and inflammatory response in patients with polycystic ovary syndrome (PCOS).Methods: 118 PCOS patients were taken as the PCOS group, and 100 healthy women of child-bearing age who underwent physical examination in our hospital during the same period were taken as the normal control group. The differences in serum Myostatin content, lipid metabolism index levels, insulin resistance index levels and inflammatory mediator contents were compared between the two groups, and the intal relationship between serum Myostatin content and the above disease-related index levels in PCOS patients was further analyzed.Results:Serum Myostatin content of PCOS group was higher than that of normal control group. Peripheral blood lipid metabolism indexes TC, LDL-C and ApoB levels of PCOS group were higher than those of normal control group whereas HDL-C and ApoA-Ⅰ levels were lower than those of normal control group; insulin resistance indexes FINS and HOMA-IR levels were higher than those of normal control group; inflammatory mediators IL-18, MCP-1 and CRP contents were higher than those of normal control group. Pearson test showed that serum Myostatin content in PCOS patients was directly correlated with the levels of the above disease-related indexes.Conclusion: Serum Myostatin content is abnormally high in PCOS patients, and the specific content is positively correlated with the disease severity.