论文部分内容阅读
目的探讨帕金森叠加综合征的临床特点、影像学特征,为临床诊断提供依据:方法按照Gilman及NIND- SPSP的诊断标准,回顾性分析32例帕金森叠加综合征患者的临床及影像学资料:结果诊断MSA32例,其中OPCA 17例、SDS9例、SND2例,诊断PSP3例、可疑1例。头颅MRI显示OPCA的主要病变在脑干、小脑;PSP的主要病变在中脑:SND病变在壳核及尾状核;而SDS仅部分有小脑病变,大部分正常;MRI检查显示21例有脑形态改变,SPECT显示MSA病例有DAT的结构和功能改变。结论帕金森叠加综合征不同临床亚型的可有不同临床特点。临床表现与头颅MRI、SPECT结合可提高OPCA、PSP、SND的诊断率,但SDS头颅MRI的诊断意义不大。
Objective To investigate the clinical features and imaging features of Parkinson’s syndrome, and to provide the basis for clinical diagnosis.Methods The clinical and imaging data of 32 patients with Parkinson’s syndrome were retrospectively analyzed according to the diagnostic criteria of Gilman and NIND-SPSP: RESULTS: There were 32 cases of MSA diagnosed, of which 17 were OPCA, 9 were SDS, 2 were SND, 3 were diagnosed as PSP and 1 was suspected. Head MRI showed that the main lesions of OPCA were in the brainstem and cerebellum. The main lesions of PSP were in the midbrain: SND lesions were in the putamen and caudate nucleus. However, the cerebellar lesions were mostly found in SDS, most of them were normal. MRI showed that 21 Morphological changes, SPECT showed MSA cases have DAT structural and functional changes. Conclusion Parkinsons syndrome may have different clinical features of different clinical subtypes. Clinical manifestations and head MRI, SPECT can improve the diagnostic rate of OPCA, PSP, SND, but the diagnosis of SDS head MRI is of little significance.