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观察大蒜素对缺氧性腺泡内肺动脉高压是否具有阻抑效应 ,在常压缺氧条件下 ,选用 42只大鼠 ,分正常组、缺氧组、缺氧加大蒜素组 ,分别在 15d和 30d测右心室收缩压 ,并利用光镜、电镜观察肺血管病变。结果大蒜素不仅能降低肺动脉压 ,减轻缺氧对内皮细胞的损伤 ,还能阻抑腺泡内肺动脉肌化增强现象。提示大蒜素有明显阻抑缺氧性腺泡内肺动脉构型重组和预防缺氧性肺动脉压升高的作用 ,从而为该药防治肺动脉高压提供了有力的实验依据
Observed whether allicin had inhibitory effect on hypoxic pulmonary hypertension in the acinar gland. Under normobaric and hypoxic conditions, 42 rats were selected and divided into normal group, hypoxia group, and hypoxia plus allicin group, respectively, on the 15th and The right ventricular systolic pressure was measured 30 days later, and pulmonary vascular lesions were observed by light and electron microscopy. Results Allicin not only reduced pulmonary artery pressure, alleviated the damage of endothelial cells caused by hypoxia, but also inhibited the enhancement of pulmonary arteries in the acinus. It is suggested that allicin can significantly inhibit the remodeling of hypoxic acinar pulmonary arteries and prevent hypoxic pulmonary hypertension, thus providing a powerful experimental basis for the prevention and treatment of pulmonary hypertension.