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目的对抗结核药物所致肝损害85例进行临床分析。方法选取六盘水市水矿集团总医院自2008年1月至2011年1月之间所收治的85例抗结核药物所致肝损害患者作为研究对象,两组患者都不再服用抗结核药物,40例治疗组患者采用5%葡萄糖250 ml+150 mg甘利欣静脉滴注的方法,每天1次;而45例对照组患者采用5%葡萄糖250 ml+20 ml门冬氨酸钾镁静脉滴注的方法,每天1次,疗程3周。在患者治疗过程中,注意观察他们的不良反应、治疗疗效,监测谷氨酰转肽酶(GGT)、门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)等。结果治疗后3周与对照组患者相比,治疗组GGT、TBiL、ALT等生化指标比较差异有统计学意义(P<0.05)。结论甘利欣治疗抗结核药物所致肝损害可以对患者的TBiL、ALT生化指标起到明显的缓解作用,且价格低廉,无不良反应,说明甘利欣在黄疸消退、降酶等方面具有较好的疗效。
Objective To combat 85 cases of liver damage caused by tuberculosis drugs for clinical analysis. Methods A total of 85 patients with liver damage caused by anti-TB drugs were selected from the General Hospital of Liupanshui Coal Mine Group from January 2008 to January 2011. The patients in both groups no longer took anti-TB drugs. Patients in the treatment group were treated with intravenous drip of 5% dextrose 250 ml + 150 mg glycyrrhizin once daily, and 45 patients in the control group received intravenous drip of 250 mg 5% glucose and 20 mg potassium magnesium aspartate Method, 1 day, 3 weeks course of treatment. During the treatment of patients, pay attention to their adverse reactions, treatment efficacy, monitoring of glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), total bilirubin (TBIL), alanine amino Transferase (ALT) and so on. Results Compared with the control group, the biochemical indexes such as GGT, TBiL, ALT in the treatment group were significantly different at 3 weeks after treatment (P <0.05). Conclusion Glycyrrhizin treatment of liver damage caused by anti-TB drugs can play a significant role in alleviating TBiL and ALT in patients with low cost and no adverse reactions, indicating that Glycyrrhizin has a good Efficacy.