类风湿关节炎(rheumatoid arthritis,RA)是一个慢性炎症性疾病。现有疗法虽能缓解部分患者的病情,但仍难尽人意,所以人们一直在探索新的疗法。随着RA免疫病理过程的进一步阐明及生物工程技术的发展,生物学疗法已试用于治疗RA。所谓生物学疗法系指用生物制剂选择性地针对免疫系统中参与炎症反应的细胞或分子而达到治疗目的。生物制剂包括由免疫细胞或参与炎症反应的细胞所产生的分子及这些分子的衍生物、拮抗物或基因重组物。 1 生物学治疗的作用点 现代研究认为,在自身免疫反应中,抗原 Rheumatoid arthritis (RA) is a chronic inflammatory disease. Although existing therapies can alleviate the condition of some patients, they are still unsatisfactory, so people are always exploring new therapies. With the further elucidation of RA immunopathological processes and the development of bioengineering techniques, biological therapies have been tried to treat RA. By biological therapy is meant the biological treatment of selectively targeting the immune system involved in the inflammatory response of cells or molecules for therapeutic purposes. Biological agents include molecules produced by immune cells or cells involved in the inflammatory response and derivatives, antagonists, or genetic recombinants of these molecules. The role of biological treatment points Modern research suggests that in the autoimmune response, antigens