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目的探讨红细胞分布宽度(RDW)与冠心病患者冠状动脉病变严重程度的关系。方法连续入选行冠脉造影患者219例,其中不稳定型心绞痛(UAP)118例,急性心肌梗死(AMI)101例,其中包括急性ST段抬高型心肌梗死(STEMI)52例,急性非ST段抬高型心肌梗死(NSTEMI)49例。所有患者均检测RDW及N末端脑钠肽前体(NT-pro BNP)等相关指标,并对患者冠脉病变情况进行SYNTAX评分,根据SYNTAX评分将所有患者分为低积分组(评分≤32分,n=139)与高积分组(评分>32分,n=80)。通过单因素分析和Pearson相关分析确定RDW与冠状动脉严重程度的关系。结果高积分组RDW〔(13.7±0.9)%〕显著高于低积分组〔(12.4±1.4)%〕,差异有统计学意义(P<0.05)。冠状动脉2支及以上病变患者的RDW显著高于单支病变组(P<0.05)。Pearson相关分析显示RDW与SYNTAX评分呈显著正相关(r=0.252,P<0.01)。NT-pro BNP升高组比NT-pro BNP正常组的RDW〔(13.4±0.8)vs.(12.5±1.0)%〕明显升高,差异有统计学意义(P<0.05)。结论冠心病患者RDW与冠心病冠脉病变严重程度具有显著相关性。
Objective To investigate the relationship between the distribution width of erythrocytes (RDW) and the severity of coronary artery disease in patients with coronary heart disease. Methods A total of 219 consecutive patients undergoing coronary angiography were enrolled. Among them, 118 were unstable angina pectoris (UAP) and 101 were acute myocardial infarction (AMI), including 52 cases of STEMI and 52 cases of acute ST-segment elevation myocardial infarction Segment elevated myocardial infarction (NSTEMI) in 49 cases. All patients were detected RDW and N-terminal pro-brain natriuretic peptide (NT-pro BNP) and other related indicators, and patients with coronary lesions SYNTAX score, according to the SYNTAX score all patients were divided into low-score group (score ≤ 32 points , n = 139) and high-score group (score> 32, n = 80). The relationship between RDW and the severity of coronary artery was determined by univariate analysis and Pearson correlation analysis. Results The RDW [(13.7 ± 0.9)%] in the high-score group was significantly higher than that in the low-score group (12.4 ± 1.4%), the difference was statistically significant (P <0.05). The RDW in patients with 2 or more coronary arteries was significantly higher than those with single vessel disease (P <0.05). Pearson correlation analysis showed a significant positive correlation between RDW and SYNTAX score (r = 0.252, P <0.01). The NT-pro BNP elevation group was significantly higher than that of the normal NT-pro BNP group (13.4 ± 0.8 vs. 12.5 ± 1.0%). The difference was statistically significant (P <0.05). Conclusion There is a significant correlation between RDW and the severity of coronary artery disease in CHD patients.