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目的探讨维吾尔族多发性骨髓瘤(MM)患者初治时外周血淋巴细胞绝对计数(ALC)与其临床特征及预后的相关性。方法回顾性分析2009年1月到2015年5月在喀什地区第一人民医院收治的50例初发维吾尔族MM患者的临床特征及生存时间,根据50例患者的ALC计算所得中位数(1.35×109/L)将患者分为两组:高ALC组(25例,ALC≥1.35×109/L)、低ALC组(25例,ALC<1.35×10~9/L),研究不同ALC水平与MM患者各临床特征的关系及其与预后的相关性。结果两组患者在性别、发病年龄、血清乳酸脱氢酶、血清白蛋白、Durie-Salmon分期、国际分期系统分期和治疗方面差异均无统计学意义(P均>0.05)。高ALC组血清β2-微球蛋白水平明显低于低ALC组(P=0.030),高ALC组患者中位生存期大于低ALC组[(21.90±4.15)个月vs(13.50±1.52)个月,P=0.046]。结论初发时ALC高的维吾尔族MM患者生存预后较好,推测ALC可能成为维吾尔族MM的独立预后因素之一。
Objective To investigate the correlation between the absolute count of peripheral blood lymphocytes (ALC) and the clinical features and prognosis of Uighur multiple myeloma (MM) patients. Methods The clinical characteristics and survival time of 50 Uighur MM patients admitted to the First People’s Hospital of Kashgar from January 2009 to May 2015 were retrospectively analyzed. The median calculated by ALC in 50 patients (1.35 The patients were divided into two groups: high ALC group (25 cases, ALC≥1.35 × 109 / L) and low ALC group (25 cases, ALC <1.35 × 10 ~ 9 / L) And the clinical characteristics of patients with MM and its relationship with the prognosis. Results There was no significant difference in sex, age of onset, serum lactate dehydrogenase, serum albumin, Durie-Salmon stage, staging and treatment of international staging system (all P> 0.05). Serum β2-microglobulin levels were significantly lower in the high ALC group than in the low ALC group (P = 0.030), and were higher in the ALC group than in the low ALC group [(21.90 ± 4.15) vs (13.50 ± 1.52) months , P = 0.046]. Conclusion The prognosis of Uighur MM patients with high ALC at initial stage is good, suggesting that ALC may be one of the independent prognostic factors of Uygur MM.