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目的探讨用γ-干扰素联合小剂量红霉素治疗小儿支气管哮喘的临床效果。方法选择2013年9月~2014年9月于该院诊治的轻、中度稳定期支气管哮喘患儿60例,随机分为对照组和观察组各30例。对照组患儿给予西医常规吸入治疗;观察组患儿则在吸入疗法基础上给予γ-干扰素联合小剂量红霉素治疗,8周为1个疗程。观察患儿临床主要症状的改善情况,并对治疗的有效率进行计算;观察治疗前后肺功能及气道反应的改善情况。结果观察组的有效率为93.33%,明显高于对照组73.33%,差异有统计学意义(P<0.05);观察组患儿经治疗后肺功能的改善情况明显优于对照组,差异有统计学意义(P<0.05);两组患儿经治疗后气道反应均明显改善,吸入组胺浓度(PC20-FEV1)值与治疗前比均有所升高,观察组患儿PC20-FEV1值为(0.8±0.5)高于对照组(0.6±0.4),差异具有统计学意义(P<0.05);对照组患儿的不良反应发生率明显高于观察组,差异具有统计学意义(P<0.05)。结论γ-干扰素联合小剂量红霉素治疗小儿支气管哮喘疗效显著,能有效改善哮喘症状,提高肺功能,改善气道反应,不良反应少,值得临床深入研究运用。
Objective To investigate the clinical effect of γ-interferon combined with low-dose erythromycin in children with bronchial asthma. Methods Sixty children with mild to moderate bronchial asthma who were diagnosed and treated in our hospital from September 2013 to September 2014 were randomly divided into control group and observation group of 30 cases. Children in the control group were given conventional western inhalation therapy. In the observation group, γ-interferon combined with low-dose erythromycin was given on the basis of inhalation therapy, and the course of treatment was 8 weeks. To observe the improvement of clinical symptoms in children, and calculate the effective rate of treatment; observe the improvement of pulmonary function and airway response before and after treatment. Results The effective rate of the observation group was 93.33%, which was significantly higher than that of the control group (73.33%), the difference was statistically significant (P <0.05). The improvement of pulmonary function in the observation group was obviously better than that of the control group (P <0.05). After treatment, the airway response of the two groups were significantly improved, and the values of PC20-FEV1 and PC20-FEV1 in both groups were significantly higher than those before treatment (0.8 ± 0.5) was higher than that of the control group (0.6 ± 0.4), the difference was statistically significant (P <0.05). The incidence of adverse reactions in children in the control group was significantly higher than that in the observation group, the difference was statistically significant (P < 0.05). Conclusion γ-interferon combined with low-dose erythromycin in children with bronchial asthma significant effect, can effectively improve the symptoms of asthma, improve lung function, improve airway response, fewer adverse reactions, it is worth further study and clinical application.