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目的:评价两种不同的钙离子通道阻滞剂对轻中度高血压合并脑卒中的治疗效果。方法:选择自2004年6月到2006年6月于我院住院治疗的高血压病合并脑卒中患者117例,随机分为尼莫通治疗组(n=64)和左旋氨氯地平治疗组(n=53)两组,随访治疗6个月,观察两组患者血压控制情况以及不良反应、脑卒中、心血管事件的发生率。结果:两组患者治疗6个月,尼莫通组血压水平与左旋氨氯地平组比较差异无统计学意义(P>0.05)4,7例患者血压控制良好,动态24 h收缩压、舒张压平均值在正常范围,但均高于左旋氨氯地平组;心脑血管事件发生率两组间比较差异无统计学意义(P>0.05)。结论:尼莫通与左旋氨氯地平两种不同的钙离子通道阻滞剂对高血压病合并脑卒中患者近期疗效类似,但左旋氨氯地平血压控制水平较好。
PURPOSE: To evaluate the therapeutic effect of two different calcium channel blockers on mild to moderate hypertension complicated with stroke. Methods: A total of 117 hypertensive patients with stroke who were hospitalized in our hospital from June 2004 to June 2006 were randomly divided into nimoton treatment group (n = 64) and levamlodipine treatment group (n = n = 53) were followed up for 6 months. The blood pressure control and the incidence of adverse reactions, stroke and cardiovascular events in two groups were observed. Results: There was no significant difference in nimodipine blood pressure level between L-amlodipine and nimodipine group (P> 0.05). The blood pressure was well controlled in 4 and 7 patients, and systolic blood pressure, diastolic blood pressure The mean values were in the normal range, but both were higher than that of levamlodipine group. There was no significant difference between the two groups in the incidence of cardiovascular events (P> 0.05). CONCLUSIONS: Two different calcium channel blockers, nimotop and levamlodipine, have similar effects on stroke in patients with hypertension and stroke, but the control of levamlodipine blood pressure is good.