论文部分内容阅读
自口服脊髓灰质炎减毒活疫苗(Oral Poliovirus Vaccine,OPV)的应用以来,全球脊髓灰质炎感染人数从1988年的350 000例下降到2010年的1 351例,然而,由于OPV使用产生的脊髓灰质炎疫苗衍生病毒(Vaccine-Derived Poliovirus,VDPV)流行,已经成为当代脊灰流行的一个新特点。本文综述了全球近十几年来报道的VDPV病例的发生与流行病学特征,以及为尽早实现全球无脊灰状态目标制定的脊灰病毒消灭策略。
Since the introduction of Oral Poliovirus Vaccine (OPV), the number of global polio infections has dropped from 350,000 in 1988 to 1 351 in 2010. However, due to the spinal cord produced by OPV use The prevalence of Vaccine-Derived Poliovirus (VDPV) has become a new feature of the current polio epidemic. This review summarizes the occurrence and epidemiological characteristics of VDPV cases reported in the world over the past decade and the poliovirus eradication strategy developed to achieve the goal of achieving a global polio-free state as soon as possible.